[Research progress of effect of neutrophil elastase and its inhibitors in sepsis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
; 34(11): 1209-1212, 2022 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-36567568
ABSTRACT
Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by infection. When an infection occurs, as the first line of defense of the body's immune system, neutrophils are first recruited to the site of infection to capture and kill pathogens by releasing neutrophil elastase (NE). However, a large amount of NE release will injury the surrounding normal tissues and induce organ dysfunction or failure. NE inhibitors can inhibit NE activity and reduce inflammatory response, which may be a promising drug for the treatment of sepsis. Currently, a variety of NE inhibitors have been developed and reported, but there is no systematic overview of their characteristics, and the role and underlying mechanisms of NE and related inhibitors in sepsis have not been thoroughly discussed. This article will make a review in this regard, in order to elucidate the effect of NE and its inhibitors in sepsis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Elastase de Leucócito
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Inibidores Enzimáticos
Idioma:
Zh
Ano de publicação:
2022
Tipo de documento:
Article