Longitudinal follow-up on vascular morphology and function in children with kidney transplants.
Acta Paediatr
; 112(3): 557-568, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36567640
ABSTRACT
AIM:
Our aim was to evaluate cardiovascular risk profile in 42 children with kidney transplants (KT) at the Queen Silvia Children's Hospital, Gothenburg Sweden.METHODS:
Forty-two children (7.1-18 years) with KT, time from transplantation 3.5 (0.9-13) years, were examined at inclusion and annually for three consecutive years. Eighteen matched controls were examined once. Cardiovascular phenotyping included ultra-high-frequency ultrasound (UHFUS), pulse wave velocity (PWV), and endothelial function.RESULTS:
Children with KT had higher body mass index (BMI) z-score and blood pressure (BP) z-score than healthy controls (BMI z-score 0.4 ± 1.0 and - 0.2 ± 0.9, respectively, p = 0.02; SBP z-score 0.5 ± 0.9 and - 0.8 ± 0.7; DBP z-score 0.7 ± 0.7 and - 0.3 ± 0.5, respectively, p < 0.001). BP z-score decreased significantly over 3 years; other vascular markers remained unchanged. PWV and carotid intima thickness (IT) were higher in children with KT compared to healthy controls. Children with pre-emptive KT had lower radial IT and dorsal pedal media thickness (MT) compared to children with preceding dialysis.CONCLUSION:
Children with KT show increased cardiovascular risk parameters, not increasing over time. Children on dialysis before KT have more pronounced vascular changes than those with pre-emptive KT, suggesting pre-emptive transplantation more beneficial for cardiovascular health.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Rigidez Vascular
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article