Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury.
J Exp Med
; 220(3)2023 03 06.
Article
em En
| MEDLINE
| ID: mdl-36571760
ABSTRACT
Functional recovery after incomplete spinal cord injury depends on the effective rewiring of neuronal circuits. Here, we show that selective chemogenetic activation of either corticospinal projection neurons or intraspinal relay neurons alone led to anatomically restricted plasticity and little functional recovery. In contrast, coordinated stimulation of both supraspinal centers and spinal relay stations resulted in marked and circuit-specific enhancement of neuronal rewiring, shortened EMG latencies, and improved locomotor recovery.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
/
Regeneração Nervosa
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article