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The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1.
Haddad Derafshi, Bahareh; Danko, Tamas; Chanda, Soham; Batista, Pedro J; Litzenburger, Ulrike; Lee, Qian Yi; Ng, Yi Han; Sebin, Anu; Chang, Howard Y; Südhof, Thomas C; Wernig, Marius.
Afiliação
  • Haddad Derafshi B; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
  • Danko T; Departments of Pathology and Chemical and Systems Biology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
  • Chanda S; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
  • Batista PJ; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
  • Litzenburger U; Departments of Pathology and Chemical and Systems Biology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
  • Lee QY; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
  • Ng YH; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
  • Sebin A; Departments of Pathology and Chemical and Systems Biology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
  • Chang HY; Center for Personal Dynamic Regulomes, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
  • Südhof TC; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Wernig M; Center for Personal Dynamic Regulomes, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.
Sci Rep ; 12(1): 22425, 2022 12 27.
Article em En | MEDLINE | ID: mdl-36575212
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Transtorno do Espectro Autista Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Transtorno do Espectro Autista Idioma: En Ano de publicação: 2022 Tipo de documento: Article