The safety of COVID-19 vaccination in immunocompromised children and young adults with immune-mediated inflammatory disease.
Acta Paediatr
; 112(4): 794-801, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36583590
ABSTRACT
AIM:
To assess safety of COVID-19 vaccination in paediatric patients with immune-mediated inflammatory disease (IMID).METHODS:
Subjects of 5-21 years of age with IMID who received at least one COVID-19 vaccine completed electronic surveys after each vaccine to assess side effects within 1 week of vaccination, current medications and COVID-19 testing after vaccination. Charts were reviewed for COVID-19 polymerase chain reaction and IgG response to SARS-CoV-2 spike protein results and for disease flare during the study period.RESULTS:
Among 190 enrolled subjects, 71% were female, with median age 17 (range 6-21) years. The most common diagnosis was juvenile idiopathic arthritis/rheumatoid arthritis (55%). 78% of subjects were taking immunosuppressive medication. At least one side effect was reported in 65% of subjects after any dose of the vaccine; with side effects in 38%, 53% and 55% of subjects after the first, second and third vaccine doses, respectively. The most common side effects were injection site pain (59%), fatigue (54%) and headache (39%). No anaphylaxis or myocarditis was reported. Three subjects (2%) experienced disease flare.CONCLUSION:
In our cohort of paediatric patients with IMID, observed side effects were found to be mild and disease flare rates were found to be low following COVID-19 vaccination.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
COVID-19
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article