Histone deacetylases inhibitor chidamide synergizes with humanized PD1 antibody to enhance T-cell chemokine expression and augment Ifn-Î³ response in NK-T cell lymphoma.

Wen, Tingyu; Sun, Guangyi; Jiang, Wenxin; He, Xiaohui; Shi, Yuankai; Ma, Fei; Liu, Peng

Wen, Tingyu; Sun, Guangyi; Jiang, Wenxin; He, Xiaohui; Shi, Yuankai; Ma, Fei; Liu, Peng.

Afiliação

Wen T; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Sun G; Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Jiang W; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
He X; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Shi Y; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address: syuankai@cicams.ac.cn.
Ma F; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address: drmafei@126.com.
Liu P; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address: liupeng@cicams.ac.cn.

EBioMedicine ; 87: 104420, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36592514

Assuntos

Quimiocinas; Interferon gama; Linfoma de Células T; Animais; Humanos; Camundongos; Anticorpos/farmacologia; Anticorpos/uso terapêutico; Linfócitos T CD8-Positivos/efeitos dos fármacos; Linfócitos T CD8-Positivos/metabolismo; Linhagem Celular Tumoral; Quimiocinas/metabolismo; Inibidores de Histona Desacetilases/farmacologia; Inibidores de Histona Desacetilases/uso terapêutico; Histona Desacetilases; Interferon gama/efeitos dos fármacos; Interferon gama/metabolismo; Linfoma/tratamento farmacológico; Linfoma de Células T/tratamento farmacológico; Recidiva Local de Neoplasia/tratamento farmacológico; Receptor de Morte Celular Programada 1/imunologia; Receptor de Morte Celular Programada 1/metabolismo

Palavras-chave

Cancer treatment combinations; H3K27ac; Immunotherapy; Pharmacology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma de Células T / Interferon gama / Quimiocinas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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