A synergistic therapeutic nano-eyedrop for dry eye disease based on ascorbic acid-coupled exosomes.
Nanoscale
; 15(4): 1890-1899, 2023 Jan 27.
Article
em En
| MEDLINE
| ID: mdl-36606731
ABSTRACT
Dry eye disease (DED), a complex ocular surface disease with a high prevalence rate, is associated with corneal injury, excess oxidative stress and inflammation. Current therapeutic strategies, including artificial tears and anti-inflammatory agents, are unable to address all the deleterious factors or to achieve a clinical cure due to their temporary or side effects. Here, we prepared a multiple-functional eyedrop based on the deposition of gold nanoparticles (AuNPs) reduced by ascorbic acid (AA) onto the exosomal phospholipid membrane of mesenchymal stem cell (mExo)-derived exosomes in situ (mExo@AA). The therapeutic value of mExo@AA for DED was demonstrated in a mouse DED model. Combining the benefits of mExo and AA, mExo@AA effectively improves corneal epithelium recovery and anti-inflammation capacity, decreases corneal reactive oxygen species, and restores tear secretion without adverse effects. Thus, this study suggests that mExo@AA is effective and safe as a therapeutic agent for the treatment of DED.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndromes do Olho Seco
/
Nanopartículas Metálicas
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Exossomos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article