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Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection.
Tawaraishi, Taisuke; Ochida, Atsuko; Akao, Yuichiro; Itono, Sachiko; Kamaura, Masahiro; Akther, Thamina; Shimada, Mitsuyuki; Canan, Stacie; Chowdhury, Sanjoy; Cao, Yafeng; Condroski, Kevin; Engkvist, Ola; Francisco, Amanda; Ghosh, Sunil; Kaki, Rina; Kelly, John M; Kimura, Chiaki; Kogej, Thierry; Nagaoka, Kazuya; Naito, Akira; Pairaudeau, Garry; Radu, Constantin; Roberts, Ieuan; Shum, David; Watanabe, Nao-Aki; Xie, Huanxu; Yonezawa, Shuji; Yoshida, Osamu; Yoshida, Ryu; Mowbray, Charles; Perry, Benjamin.
Afiliação
  • Tawaraishi T; Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chrome, Fujisawa, Kanagawa 251-8555, Japan.
  • Ochida A; Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chrome, Fujisawa, Kanagawa 251-8555, Japan.
  • Akao Y; Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chrome, Fujisawa, Kanagawa 251-8555, Japan.
  • Itono S; Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chrome, Fujisawa, Kanagawa 251-8555, Japan.
  • Kamaura M; Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chrome, Fujisawa, Kanagawa 251-8555, Japan.
  • Akther T; Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chrome, Fujisawa, Kanagawa 251-8555, Japan.
  • Shimada M; Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chrome, Fujisawa, Kanagawa 251-8555, Japan.
  • Canan S; Celgene Corporation, Celgene Global Health, 10300 Campus Point Drive, San Diego, California 92121, United States.
  • Chowdhury S; TCG Lifesciences, Plot No-7, Salt Lake Electronics Complex, BN Block, Sector V, Kolkata 700091, India.
  • Cao Y; WuXi AppTec Company Ltd., 666 Gaoxin Road, East Lake High-Tech Development Zone, Wuhan 430075, People's Republic of China.
  • Condroski K; Celgene Corporation, Celgene Global Health, 10300 Campus Point Drive, San Diego, California 92121, United States.
  • Engkvist O; AstraZeneca Discovery Sciences, R&D, Pepparedsleden 1, 431 50 Mölndal, Sweden.
  • Francisco A; London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.
  • Ghosh S; TCG Lifesciences, Plot No-7, Salt Lake Electronics Complex, BN Block, Sector V, Kolkata 700091, India.
  • Kaki R; Shionogi & Co., Ltd, 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan.
  • Kelly JM; London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.
  • Kimura C; Shionogi & Co., Ltd, 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan.
  • Kogej T; AstraZeneca Discovery Sciences, R&D, Pepparedsleden 1, 431 50 Mölndal, Sweden.
  • Nagaoka K; Eisai Co., Ltd, 1-3, Tokodai 5-chome, Tsukuba, Ibaraki 300-2635, Japan.
  • Naito A; Shionogi & Co., Ltd, 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan.
  • Pairaudeau G; AstraZeneca, Discovery Sciences, R&D, The Darwin Building, 310 Milton Road, Milton, Cambridge CB4 0WG, U.K.
  • Radu C; Institut Pasteur Korea, 16, Daewangpangyo-ro 712 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
  • Roberts I; AstraZeneca, Discovery Sciences, R&D, The Darwin Building, 310 Milton Road, Milton, Cambridge CB4 0WG, U.K.
  • Shum D; Institut Pasteur Korea, 16, Daewangpangyo-ro 712 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
  • Watanabe NA; Eisai Co., Ltd, 1-3, Tokodai 5-chome, Tsukuba, Ibaraki 300-2635, Japan.
  • Xie H; WuXi AppTec Company Ltd., 666 Gaoxin Road, East Lake High-Tech Development Zone, Wuhan 430075, People's Republic of China.
  • Yonezawa S; Shionogi & Co., Ltd, 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan.
  • Yoshida O; Shionogi & Co., Ltd, 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan.
  • Yoshida R; Shionogi & Co., Ltd, 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan.
  • Mowbray C; Drugs for Neglected Diseases Initiative, 15 Chemin Camille Vidart, Geneva 1202, Switzerland.
  • Perry B; Drugs for Neglected Diseases Initiative, 15 Chemin Camille Vidart, Geneva 1202, Switzerland.
J Med Chem ; 66(2): 1221-1238, 2023 01 26.
Article em En | MEDLINE | ID: mdl-36607408
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma cruzi / Doença de Chagas Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma cruzi / Doença de Chagas Idioma: En Ano de publicação: 2023 Tipo de documento: Article