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Effects of anterior thalamic nucleus DBS on interictal heart rate variability in patients with refractory epilepsy.
Lorincz, Katalin; Bóné, Beáta; Karádi, Kázmér; Kis-Jakab, Greta; Tóth, Natália; Halász, László; Eross, Loránd; Balás, István; Faludi, Béla; Jordán, Zsófia; Chadaide, Zoltan; Gyimesi, Csilla; Fabó, Dániel; Janszky, József.
Afiliação
  • Lorincz K; Department of Neurology, Medical School, University of Pecs, Ret u. 2, H-7623 Pecs, Hungary; Department of Neurosurgery, University Hospital Tübingen, Eberhard Karls University, Hoppe-Seyler str. 3, 72076 Tübingen, Germany. Electronic address: lorinczkati@gmail.com.
  • Bóné B; Department of Neurology, Medical School, University of Pecs, Ret u. 2, H-7623 Pecs, Hungary.
  • Karádi K; Department of Behavioral Sciences, Medical School, University of Pecs, Szigeti u.12, H-7624 Pecs, Hungary.
  • Kis-Jakab G; Department of Neurology, Medical School, University of Pecs, Ret u. 2, H-7623 Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Ret u. 2., H-7623 Pecs, Hungary.
  • Tóth N; Department of Neurology, Medical School, University of Pecs, Ret u. 2, H-7623 Pecs, Hungary.
  • Halász L; Department of Functional Neurosurgery, National Institute of Neurosciences, Amerikai ut 57, H-1345 Budapest, Hungary.
  • Eross L; Department of Functional Neurosurgery, National Institute of Neurosciences, Amerikai ut 57, H-1345 Budapest, Hungary.
  • Balás I; Department of Neurosurgery, Medical School, University of Pecs, Ret u. 2, H-7623 Pecs, Hungary.
  • Faludi B; Department of Neurology, Medical School, University of Pecs, Ret u. 2, H-7623 Pecs, Hungary.
  • Jordán Z; Department of Neurology, National Institute of Neurosciences, Amerikai ut 57., H-1345 Budapest, Hungary.
  • Chadaide Z; University of Szeged Albert Szentgyörgyi Medical School, Tisza Lajos krt.109, 6725 Szeged, Hungary.
  • Gyimesi C; Department of Neurology, Medical School, University of Pecs, Ret u. 2, H-7623 Pecs, Hungary.
  • Fabó D; Department of Neurology, National Institute of Neurosciences, Amerikai ut 57., H-1345 Budapest, Hungary.
  • Janszky J; Department of Neurology, Medical School, University of Pecs, Ret u. 2, H-7623 Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Ret u. 2., H-7623 Pecs, Hungary.
Clin Neurophysiol ; 147: 17-30, 2023 03.
Article em En | MEDLINE | ID: mdl-36630886
ABSTRACT

OBJECTIVE:

Heart rate variability (HRV) changes were investigated by several studies after resective epilepsy surgery/vagus nerve stimulation. We examined anterior thalamic nucleus (ANT)-deep brain stimulation (DBS) effects on HRV parameters.

METHODS:

We retrospectively analyzed 30 drug-resistant epilepsy patients' medical record data and collected electrocardiographic epochs recorded during video- electroencephalography monitoring sessions while awake and during N1- or N2-stage sleep pre-DBS implantation surgery, post-surgery but pre-stimulation, and after stimulation began.

RESULTS:

The mean square root of the mean squared differences between successive RR intervals and RR interval standard deviation values differed significantly (p < 0.05) among time-points, showing increased HRV post-surgery. High (0.15-0.4 Hz) and very low frequency (<0.04 Hz) increased, while low frequency (0.04-0.15 Hz) and the LF/HF ratio while awake decreased, suggesting improved autonomic regulation post-surgery. Change of effect size was larger in patients where both activated contacts were located in the ANT than in those where only one or none of the contacts hit the ANT.

CONCLUSIONS:

In patients with drug-resistant epilepsy, ANT-DBS might positively influence autonomic regulation, as reflected by increased HRV.

SIGNIFICANCE:

To gain a more comprehensive outcome estimation after DBS implantation, we suggest including HRV measures with seizure count in the post-surgery follow-up protocol.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Núcleos Anteriores do Tálamo / Estimulação Encefálica Profunda / Epilepsia / Epilepsia Resistente a Medicamentos Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Núcleos Anteriores do Tálamo / Estimulação Encefálica Profunda / Epilepsia / Epilepsia Resistente a Medicamentos Idioma: En Ano de publicação: 2023 Tipo de documento: Article