SATB2, coordinated with CUX1, regulates IL-1ß-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16<sup>INK4a</sup> expression.

Wu, Ting; Wu, Yuwei; Jiang, Danli; Sun, Wei; Zou, Meijuan; Vasamsetti, Sathish Babu; Dutta, Partha; Leers, Steven A; Di, Wu; Li, Gang

SATB2, coordinated with CUX1, regulates IL-1ß-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16^INK4a expression.

Wu, Ting; Wu, Yuwei; Jiang, Danli; Sun, Wei; Zou, Meijuan; Vasamsetti, Sathish Babu; Dutta, Partha; Leers, Steven A; Di, Wu; Li, Gang.

Afiliação

Wu T; Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wu Y; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jiang D; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sun W; Department of Medicine, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Zou M; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Vasamsetti SB; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pennsylvania, Pittsburgh, USA.
Dutta P; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Leers SA; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pennsylvania, Pittsburgh, USA.
Di W; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pennsylvania, Pittsburgh, USA.
Li G; UPMC Vascular Laboratories, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Aging Cell ; 22(2): e13765, 2023 02.

Article em En | MEDLINE | ID: mdl-36633253

Assuntos

Aterosclerose; Proteínas de Ligação à Região de Interação com a Matriz; Humanos; Aterosclerose/genética; Senescência Celular/genética; Inibidor p16 de Quinase Dependente de Ciclina/genética; Inibidor p16 de Quinase Dependente de Ciclina/metabolismo; Células Endoteliais/metabolismo; Estudo de Associação Genômica Ampla; Proteínas de Homeodomínio/genética; Proteínas de Ligação à Região de Interação com a Matriz/genética; Fenótipo; Proteínas Repressoras/genética; Fatores de Transcrição/genética; Interferon beta-1b/farmacologia

Palavras-chave

aging; aging-related diseases; atherosclerosis; cellular senescence; endothelial cells; post-GWAS functional analysis; senescence-associated secretory phenotype (SASP); single nucleotide polymorphism (SNP)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação à Região de Interação com a Matriz / Aterosclerose Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google