Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.

Deng, Sunbin; Gardner, Sarah M; Gottlieb, Leah; Pan, Buyan; Petersson, E James; Marmorstein, Ronen

Deng, Sunbin; Gardner, Sarah M; Gottlieb, Leah; Pan, Buyan; Petersson, E James; Marmorstein, Ronen.

Afiliação

Deng S; Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gardner SM; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Gottlieb L; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Pan B; Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA.
Petersson EJ; Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Marmorstein R; Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, Perelman School of Me

Structure ; 31(2): 166-173.e4, 2023 02 02.

Article em En | MEDLINE | ID: mdl-36638802

Assuntos

Acetiltransferase N-Terminal C; Proteínas de Saccharomyces cerevisiae; Humanos; Acetilação; Sequência de Aminoácidos; Acetiltransferase N-Terminal C/metabolismo; Ribossomos/metabolismo; Saccharomyces cerevisiae/metabolismo; Proteínas de Saccharomyces cerevisiae/metabolismo; Biocatálise

Palavras-chave

N-terminal acetylation; N-terminal acetyltransferase; NATs; NatC; co-translational modification; enzyme mechanism; ribosome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Saccharomyces cerevisiae / Acetiltransferase N-Terminal C Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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