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Carrier protein mediated cargo sensing in quorum signal synthases.
Fischer, Patrick D; Chowdhury, Abu Sayeed; Bartholow, Thomas; Basu, Shibani; Baggs, Eric; Cox, Huel S; Matosin, Srdan; Burkart, Michael D; Warner, Lisa; Nagarajan, Rajesh; Arthanari, Haribabu.
Afiliação
  • Fischer PD; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. hari@hms.harvard.edu.
  • Chowdhury AS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Bartholow T; Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrucken, Germany.
  • Basu S; Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, USA.
  • Baggs E; Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA.
  • Cox HS; Department of Chemistry and Biochemistry, Boise State University, Boise, ID, USA. rajnagarajan@boisestate.edu.
  • Matosin S; Department of Chemistry and Biochemistry, Boise State University, Boise, ID, USA. rajnagarajan@boisestate.edu.
  • Burkart MD; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. hari@hms.harvard.edu.
  • Warner L; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Nagarajan R; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. hari@hms.harvard.edu.
  • Arthanari H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Chem Commun (Camb) ; 59(8): 1014-1017, 2023 Jan 24.
Article em En | MEDLINE | ID: mdl-36645064
ABSTRACT
Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein-enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Proteínas de Transporte Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Proteínas de Transporte Idioma: En Ano de publicação: 2023 Tipo de documento: Article