Atomic layer deposition (ALD)-constructed TaS2nanoflakes for cancer-related nucleolin detection.
Nanotechnology
; 34(17)2023 Feb 10.
Article
em En
| MEDLINE
| ID: mdl-36645911
ABSTRACT
Sensitive detection of nucleolin (NCL) is of great significance for the early diagnosis of cancer. In this work, as a new type of two-dimensional (2D) transition metal dichalcogenides (TMDCs), TaS2nanoflakes (NFs) were precisely constructed by atomic layer deposition (ALD) on carbon fiber paper (CFP) with high specific surface area.In situobservation showed that the nucleation and growth of TaS2nanoflakes were precisely controlled by the number of ALD cycles, thereby regulating their electrochemical properties. The electrochemical performance of TaS2NFs was observed in depth, and compared with that of traditional 2D TMDCs. Due to the high surface area and conductivity, anodic/cathodic current of â¼1570µA of TaS2NFs/CFP can be obtained. Subsequently, an electrochemical biosensor based on ALD-constructed TaS2NFs/CFP for cancer-related NCL detection was fabricated. Due to the excellent electrochemical performance of TaS2NFs/CFP, ultrasensitive detection of NCL in the linear range of 0.1 pM-10 nM with a detection limit of 0.034 pM was achieved.
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Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Neoplasias
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article