An herbal formulation "Shenshuaifu Granule" alleviates cisplatin-induced nephrotoxicity by suppressing inflammation and apoptosis through inhibition of the TLR4/MyD88/NF-&#954;B pathway.

Jin, Xiaoming; He, Riming; Liu, Jiahui; Wang, Yuzhi; Li, Zhongtang; Jiang, Beibei; Lu, Jiandong; Yang, Shudong

An herbal formulation "Shenshuaifu Granule" alleviates cisplatin-induced nephrotoxicity by suppressing inflammation and apoptosis through inhibition of the TLR4/MyD88/NF-κB pathway.

Jin, Xiaoming; He, Riming; Liu, Jiahui; Wang, Yuzhi; Li, Zhongtang; Jiang, Beibei; Lu, Jiandong; Yang, Shudong.

Afiliação

Jin X; Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China.
He R; Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China.
Liu J; Shenzhen Traditional Chinese Medicine Hospital Afï¬liated to Nanjing University of Chinese Medicine, Shenzhen, Guangdong, 518033, China.
Wang Y; Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China.
Li Z; Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China.
Jiang B; Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China.
Lu J; Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Nanjing University of Chinese Medicine, Shenzhen, 518033, China. Electronic address: 20213184@njucm.edu.cn.
Yang S; Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China. Electronic address: shudong_yang@126.com.

J Ethnopharmacol ; 306: 116168, 2023 Apr 24.

Article em En | MEDLINE | ID: mdl-36646160

Assuntos

Cisplatino; NF-kappa B; Camundongos; Animais; NF-kappa B/metabolismo; Cisplatino/farmacologia; Receptor 4 Toll-Like/metabolismo; Fator 88 de Diferenciação Mieloide/metabolismo; Simulação de Acoplamento Molecular; Inflamação/induzido quimicamente; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Apoptose

Palavras-chave

A herbal formulation; Apoptosis; Cisplatin-induced nephrotoxicity; Inflammation; The TLR4/MyD88/NF-κB pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Cisplatino Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Cisplatino Idioma: En Ano de publicação: 2023 Tipo de documento: Article