Retinopathy of prematurity: risk stratification by gestational age.
J Perinatol
; 43(6): 694-701, 2023 06.
Article
em En
| MEDLINE
| ID: mdl-36653668
ABSTRACT
OBJECTIVE:
To identify gestational age (GA) specific risk factors for severe ROP (sROP). STUDYDESIGN:
Single-center cohort stratified by GA into <24 weeks, 24-26 weeks and ≥27 weeks.RESULTS:
132/1106 (11.9%) developed sROP. Time to full feeds was the only risk factor [HR 1.003 (1.001-1.006), p = 0.04] for infants<24 weeks GA. For infants 24-26 weeks GA, a higher GA was protective [HR 0.66 (0.51-0.85), p < 0.01], whereas steroids for bronchopulmonary dysplasia (BPD) [HR 2.21 (1.28-3.26), p < 0.01], patent ductus arteriosus (PDA) ligation [HR 1.99 (1.25-3.11), p < 0.01] and use of nitric oxide [HR 1.96 (1.11-3.30), p = 0.01] increased the hazard of sROP. Increasing birthweight was protective [HR 0.70 (0.54-0.89), p < 0.01] in infants ≥27 weeks GA. Cumulative hazard of sROP reached 1.0 by fifteen weeks for <24 weeks GA, 0.4 by twenty weeks for 24-26 weeks GA, and 0.05 by twenty weeks after birth for ≥27 weeks GA.CONCLUSIONS:
Risk factors, cumulative hazard, and time to sROP vary by GA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Retinopatia da Prematuridade
/
Permeabilidade do Canal Arterial
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article