Small cell neuroendocrine carcinoma with primary orbital involvement - The unseen, and a review of literature.
Indian J Pathol Microbiol
; 66(1): 155-158, 2023.
Article
em En
| MEDLINE
| ID: mdl-36656229
ABSTRACT
Neuroendocrine neoplasms are derived from the epithelial lineages mainly of respiratory tract, with predominant neuroendocrine differentiation. There are only a handful of documented cases of paranasal small cell neuroendocrine carcinomas (SNEC) with primary orbital involvement. Here, the authors describe a 33-year-old male patient with rapidly progressive swelling of the right lower lid with proptosis since 4 weeks. On contrast-MRI orbit, an ill-defined multilobulated mass measuring 3.6 × 3.1 cm with intense homogenous enhancement was seen in the right retrobulbar space involving the right ethmoid sinus. On incisional biopsy, a poorly differentiated mass containing numerous small round blue cells and scanty intervening stroma with prominent necrosis and apoptosis was seen. Immunohistochemistry was strongly positive for synaptophysin. He was diagnosed as a case of SNEC and received chemotherapy, with good response till date of 9 months of follow up. The authors present a literature review and describe challenges in management of a primary orbital SNEC.
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MEDLINE
Assunto principal:
Neoplasias Orbitárias
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Neoplasias dos Seios Paranasais
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Tumores Neuroendócrinos
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Carcinoma de Células Pequenas
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Carcinoma Neuroendócrino
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article