The ends in sight: Mre11-Rad50-Nbs1 complex structures come into focus.

Wojtaszek, Jessica L; Williams, R Scott

Wojtaszek, Jessica L; Williams, R Scott.

Afiliação

Wojtaszek JL; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Durham, Research Triangle Park, NC 27709, USA.
Williams RS; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Durham, Research Triangle Park, NC 27709, USA. Electronic address: williamsrs@niehs.nih.gov.

Mol Cell ; 83(2): 160-162, 2023 Jan 19.

Article em En | MEDLINE | ID: mdl-36669476

RESUMO

In this issue of Molecular Cell, Rotheneder et al.1 elucidate the eukaroytic Mre11-Rad50-Nbs1 (MRN) complex quaternary architecture, which together with cryo-EM structures of bacterial Mre11-Rad50-DNA complexes,2 resolves the basis for MRN assembly and its broad nuclease specificity regulating DNA double-strand break repair.

Assuntos

Proteínas de Ciclo Celular; Enzimas Reparadoras do DNA; Proteína Homóloga a MRE11/genética; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Enzimas Reparadoras do DNA/genética; Enzimas Reparadoras do DNA/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Reparo do DNA; DNA/genética; Hidrolases Anidrido Ácido/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ciclo Celular / Enzimas Reparadoras do DNA Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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