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Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes.
Schmidt, Amand F; Joshi, Roshni; Gordillo-Marañón, Maria; Drenos, Fotios; Charoen, Pimphen; Giambartolomei, Claudia; Bis, Joshua C; Gaunt, Tom R; Hughes, Alun D; Lawlor, Deborah A; Wong, Andrew; Price, Jackie F; Chaturvedi, Nishi; Wannamethee, Goya; Franceschini, Nora; Kivimaki, Mika; Hingorani, Aroon D; Finan, Chris.
Afiliação
  • Schmidt AF; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK. amand.schmidt@ucl.ac.uk.
  • Joshi R; UCL BHF Research Accelerator Centre, London, UK. amand.schmidt@ucl.ac.uk.
  • Gordillo-Marañón M; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. amand.schmidt@ucl.ac.uk.
  • Drenos F; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. amand.schmidt@ucl.ac.uk.
  • Charoen P; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
  • Giambartolomei C; UCL BHF Research Accelerator Centre, London, UK.
  • Bis JC; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
  • Gaunt TR; UCL BHF Research Accelerator Centre, London, UK.
  • Hughes AD; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
  • Lawlor DA; Department of Life Sciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, UK.
  • Wong A; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
  • Price JF; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
  • Chaturvedi N; Integrative Computational BioScience (ICBS) Center, Mahidol University, Bangkok, 10400, Thailand.
  • Wannamethee G; Istituto Italiano di Tecnologia, Non-coding RNAs and RNA-based Therapeutics, Via Morego, 30, 16163, Genova, Italy.
  • Franceschini N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Kivimaki M; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.
  • Hingorani AD; NIHR Bristol Biomedical Research Centre, University Hospitals Bristol National Health Service Foundation Trust and University of Bristol, Bristol, UK.
  • Finan C; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK.
Commun Med (Lond) ; 3(1): 9, 2023 Jan 20.
Article em En | MEDLINE | ID: mdl-36670186
It is known that increases in the amount of certain fats and proteins in the blood can lead to heart attacks. These increases are also found in people with other diseases. Here, we looked at inherited differences in some fats and proteins in blood to explore whether these could be associated with various diseases. We found that some fats and proteins in blood were associated with heart disease (including heart failure), blood pressure, blockages in blood vessels, and to a lesser extent with diabetes, Alzheimer's disease, and inflammatory bowel disease. These findings suggest that changes to lipids and proteins in the blood might lead to various diseases, including some that are not normally associated with changes in the blood. Monitoring these changes could improve diagnosis and treatment of these diseases.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article