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Neurocognitive Endophenotypes for Eating Disorders: A Preliminary High-Risk Family Study.
Pappaianni, Edoardo; Barona, Manuela; Doucet, Gaelle E; Clark, Christopher; Frangou, Sophia; Micali, Nadia.
Afiliação
  • Pappaianni E; Mental Health Services in the Capital Region of Denmark, Eating Disorders Research Unit, Psychiatric Center Ballerup, 2750 Ballerup, Denmark.
  • Barona M; Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
  • Doucet GE; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
  • Clark C; Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
  • Frangou S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Micali N; Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Brain Sci ; 13(1)2023 Jan 04.
Article em En | MEDLINE | ID: mdl-36672080
Eating disorders (EDs) are psychiatric disorders with a neurobiological basis. ED-specific neuropsychological and brain characteristics have been identified, but often in individuals in the acute phase or recovered from EDs, precluding an understanding of whether they are correlates and scars of EDs vs. predisposing factors. Although familial high-risk (FHR) studies are available across other disorders, this study design has not been used in EDs. We carried out the first FMH study in EDs, investigating healthy offspring of women with EDs and controls. We preliminarily aimed to investigate ED-related neurocognitive and brain markers that could point to predisposing factors for ED. Sixteen girls at FHR for EDs and twenty control girls (age range: 8−15), completed neuropsychological tests assessing executive functions. Girls also underwent a resting-state fMRI scan to quantify functional connectivity (FC) within resting-state networks. Girls at FHR for EDs performed worse on a cognitive flexibility task compared with controls (F = 5.53, p = 0.02). Moreover, they showed different FC compared with controls in several resting-state networks (p < 0.05 FDR-corrected). Differences identified in cognitive flexibility and in FC are in line with those identified in individuals with EDs, strongly pointing to a role as potential endophenotypes of EDs.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article