PREDICT-crFMF score: A novel model for predicting colchicine resistance in children with familial Mediterranean fever.
Mod Rheumatol
; 34(1): 220-225, 2023 Dec 22.
Article
em En
| MEDLINE
| ID: mdl-36680425
ABSTRACT
OBJECTIVES:
To develop a novel scoring system to predict colchicine resistance in Familial Mediterranean fever (FMF) based on the initial features of the patients.METHODS:
The medical records of patients were analyzed prior to the initiation of colchicine. After generating a predictive score in the initial cohort, it was applied to an independent cohort for external validation of effectiveness and reliability.RESULTS:
Among 1418 patients with FMF, 56 (3.9%) were colchicine resistant (cr) and 1312 (96.1%) were colchicine responsive. Recurrent arthritis (4 points), protracted febrile myalgia (8 points), erysipelas-like erythema (2 points), exertional leg pain (2 points), and carrying M694V homozygous mutation (4 points) were determined as the parameters for predicting cr-FMF in the logistic regression model. The cut-off value of 9 was 87% sensitive and 82% specific to foresee the risk of cr-FMF in the receiver operating characteristic. Validation of the scoring system with an independent group (cr-FMF = 107, colchicine responsive = 1935) revealed that the cut-off value was 82% sensitive and 79% specific to identify the risk of cr-FMF.CONCLUSIONS:
By constructing this reliable and predictor tool, we enunciate that predicting cr-FMF at the initiation of the disease and interfering timely before the emergence of complications will be possible.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Febre Familiar do Mediterrâneo
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Artrite
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article