Anti-inflammatory activities of <i>Coleus forsteri</i> (formerly <i>Plectranthus forsteri</i>) extracts on human macrophages and chemical characterization.

Nicolas, Mael; Lasalo, Malia; Chow, Sharron; Antheaume, Cyril; Huet, Karl; Hnawia, Edouard; Guillemin, Gilles J; Nour, Mohammed; Matsui, Mariko

Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization.

Nicolas, Mael; Lasalo, Malia; Chow, Sharron; Antheaume, Cyril; Huet, Karl; Hnawia, Edouard; Guillemin, Gilles J; Nour, Mohammed; Matsui, Mariko.

Afiliação

Nicolas M; Département de Chimie, Université Côte d'Azur, Nice, France.
Lasalo M; Group Bioactivities of Natural compounds and derivatives (BIONA), Formerly Group Immunity and Inflammation (GIMIN), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia.
Chow S; Neuroinflammation Group, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Antheaume C; Institut de Science et d'Ingénierie Supramoléculaires, Université de Strasbourg, Strasbourg, France.
Huet K; Group Bioactivities of Natural compounds and derivatives (BIONA), Formerly Group Immunity and Inflammation (GIMIN), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia.
Hnawia E; PHARMADEV, UMR152, Institut de Recherche pour le Développement (IRD), Noumea Center, Noumea, New Caledonia.
Guillemin GJ; Neuroinflammation Group, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Nour M; Institut des Sciences Exactes et Appliqués (ISEA), EA7484, Université de Nouvelle-Calédonie, Noumea, New Caledonia.
Matsui M; Group Bioactivities of Natural compounds and derivatives (BIONA), Formerly Group Immunity and Inflammation (GIMIN), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea, New Caledonia.

Front Pharmacol ; 13: 1081310, 2022.

Article em En | MEDLINE | ID: mdl-36699063

ABSTRACT

ABSTRACT

Introduction:

Formerly named Plectranthus forsteri, Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant.

Method:

Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers.

Results:

Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U (1), coleon U-quinone (2), 8α,9α-epoxycoleon U-quinone (3), horminone or 7α-hydroxyroyleanone (4), 6ß,7α-dihydroxyroyleanone (5), 7α-acetoxy-6ß-hydroxyroyleanone (6) and 7α-formyloxy-6ß-hydroxyroyleanone (7).