Design, synthesis and in vitro biological evaluation of 2-aminopyridine derivatives as novel PI3KÎ´ inhibitors for hematological cancer.

Yang, Chengbin; Gong, Yimin; Gao, Yunjian; Deng, Mingli; Liu, Xiaofeng; Yang, Yongtai; Ling, Yun; Jia, Yu; Zhou, Yaming

Yang, Chengbin; Gong, Yimin; Gao, Yunjian; Deng, Mingli; Liu, Xiaofeng; Yang, Yongtai; Ling, Yun; Jia, Yu; Zhou, Yaming.

Afiliação

Yang C; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China; Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
Gong Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
Gao Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
Deng M; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
Liu X; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
Yang Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
Ling Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
Jia Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China. Electronic address: yujia@fudan.edu.cn.
Zhou Y; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China. Electronic address: ymzhou@fudan.edu.cn.

Bioorg Med Chem Lett ; 82: 129152, 2023 02 15.

Article em En | MEDLINE | ID: mdl-36706844

Assuntos

Antineoplásicos; Neoplasias Hematológicas; Neoplasias; Humanos; Inibidores de Proteínas Quinases/química; Fosfatidilinositol 3-Quinases; Classe I de Fosfatidilinositol 3-Quinases; Proliferação de Células; Antineoplásicos/química; Linhagem Celular Tumoral

Palavras-chave

2-aminopyridine; Hematological malignancies; PI3KÎ´ inhibitor; Phosphatidylinositol 3-kinase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Hematológicas / Neoplasias / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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