The importance of thyroid hormone signaling during early development: Lessons from the zebrafish model.
Gen Comp Endocrinol
; 334: 114225, 2023 04 01.
Article
em En
| MEDLINE
| ID: mdl-36709002
ABSTRACT
The zebrafish is an optimal experimental model to study thyroid hormone (TH) involvement in vertebrate development. The use of state-of-the-art zebrafish genetic tools available for the study of the effect of gene silencing, cell fate decisions and cell lineage differentiation have contributed to a more insightful comprehension of molecular, cellular, and tissue-specific TH actions. In contrast to intrauterine development, extrauterine embryogenesis observed in zebrafish has facilitated a more detailed study of the development of the hypothalamic-pituitary-thyroid axis. This model has also enabled a more insightful analysis of TH molecular actions upon the organization and function of the brain, the retina, the heart, and the immune system. Consequently, zebrafish has become a trendy model to address paradigms of TH-related functional and biomedical importance. We here compilate the available knowledge regarding zebrafish developmental events for which specific components of TH signaling are essential.
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Base de dados:
MEDLINE
Assunto principal:
Hormônios Tireóideos
/
Peixe-Zebra
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article