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Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.
Luppi, Andrea I; Vohryzek, Jakub; Kringelbach, Morten L; Mediano, Pedro A M; Craig, Michael M; Adapa, Ram; Carhart-Harris, Robin L; Roseman, Leor; Pappas, Ioannis; Peattie, Alexander R D; Manktelow, Anne E; Sahakian, Barbara J; Finoia, Paola; Williams, Guy B; Allanson, Judith; Pickard, John D; Menon, David K; Atasoy, Selen; Stamatakis, Emmanuel A.
Afiliação
  • Luppi AI; Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK. al857@cam.ac.uk.
  • Vohryzek J; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK. al857@cam.ac.uk.
  • Kringelbach ML; Leverhulme Centre for the Future of Intelligence, University of Cambridge, Cambridge, CB2 1SB, UK. al857@cam.ac.uk.
  • Mediano PAM; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
  • Craig MM; Center for Music in the Brain, Aarhus University, Aarhus, Denmark.
  • Adapa R; Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, 08005, Spain.
  • Carhart-Harris RL; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
  • Roseman L; Center for Music in the Brain, Aarhus University, Aarhus, Denmark.
  • Pappas I; Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
  • Peattie ARD; Department of Computing, Imperial College London, London, W12 0NN, UK.
  • Manktelow AE; Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Sahakian BJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Finoia P; Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Williams GB; Center for Psychedelic Research, Department of Brain Sciences, Imperial College London, London, W12 0NN, UK.
  • Allanson J; Psychedelics Division - Neuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, 94143, USA.
  • Pickard JD; Center for Psychedelic Research, Department of Brain Sciences, Imperial College London, London, W12 0NN, UK.
  • Menon DK; Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Atasoy S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Stamatakis EA; Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Commun Biol ; 6(1): 117, 2023 01 28.
Article em En | MEDLINE | ID: mdl-36709401
A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations of consciousness into distributed patterns of structure-function dependence across scales: the harmonic modes of the human structural connectome. We show that structure-function coupling is a generalisable indicator of consciousness that is under bi-directional neuromodulatory control. We find increased structure-function coupling across scales during loss of consciousness, whether due to anaesthesia or brain injury, capable of discriminating between behaviourally indistinguishable sub-categories of brain-injured patients, tracking the presence of covert consciousness. The opposite harmonic signature characterises the altered state induced by LSD or ketamine, reflecting psychedelic-induced decoupling of brain function from structure and correlating with physiological and subjective scores. Overall, connectome harmonic decomposition reveals how neuromodulation and the network architecture of the human connectome jointly shape consciousness and distributed functional activation across scales.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Conectoma / Alucinógenos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Conectoma / Alucinógenos Idioma: En Ano de publicação: 2023 Tipo de documento: Article