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In vitro-in vivo correlation in nanocarriers: From protein corona to therapeutic implications.
Agnihotri, Tejas Girish; Alexander, Amit; Agrawal, Mukta; Dubey, Sunil Kumar; Jain, Aakanchha.
Afiliação
  • Agnihotri TG; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Palaj, Gandhinagar 382355, Gujarat, India.
  • Alexander A; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Sila village, Nizsundarighopa, Changsari, Assam 781101, India.
  • Agrawal M; School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Polepally SEZ, TSIIC, Jadcherla, Mahbubnagar, Hyderabad 509301, India.
  • Dubey SK; R&D Healthcare Division, Emami Ltd, 13, BT Road, Belgharia, Kolkata 700056, India. Electronic address: sunilkumar.dubey@emamigroup.com.
  • Jain A; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Palaj, Gandhinagar 382355, Gujarat, India. Electronic address: aakanchha.jain@niperahm.res.in.
J Control Release ; 354: 794-809, 2023 02.
Article em En | MEDLINE | ID: mdl-36709923
Understanding and establishing a link between the physicochemical characteristics of nanoparticles (NPs) and their biological interactions poses to be a great challenge in the field of nanotherapeutics. Recent analytical advancements concerning bio-nanointerfaces have accelerated the quest to comprehend the fate of nanocarrier systems in vivo. Scientists have discovered that protein corona, an adsorbed layer of biomolecules on the surface of NPs takes a leading part in interacting with cells and in the cellular uptake process, thereby determining the in vivo behaviour of NPs. Another useful method to assess the in vivo fate of NPs is by performing dissolution testing. This forms the basis for in vitro in vivo correlation (IVIVC), relating in vitro dissolution of NPs and their in vivo properties. Scientists are continuously directing their efforts towards establishing IVIVC for different nanocarrier systems while concurrently gaining insights into protein corona. This review primarily summarizes the importance of protein corona and its interaction with nanoparticles. It also gives an insight into the factors affecting the interaction and various in vitro dissolution media used for varied nanocarrier systems. The article concludes with a discussion of the limitations of IVIVC modelling and its position from a regulatory perspective.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Coroa de Proteína Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Coroa de Proteína Idioma: En Ano de publicação: 2023 Tipo de documento: Article