Christmas-Related Reduction in Beta Activity in Parkinson's Disease.
Mov Disord
; 38(4): 692-697, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36718788
ABSTRACT
BACKGROUND:
Subthalamic nucleus (STN) beta (13 - 35 Hz) activity is a biomarker reflecting motor state in Parkinson's disease (PD). Adaptive deep brain stimulation (DBS) aims to use beta activity for therapeutic adjustments, but many aspects of beta activity in real-life situations are unknown.OBJECTIVE:
The aim was to investigate Christmas-related influences on beta activity in PD.METHODS:
Differences in Christmas Day to nonfestive daily averages in chronic biomarker recordings in 4 PD patients with a sensing-enabled STN DBS implant were retrospectively analyzed. Sweet-spot and whole-brain network connectomic analyses were performed.RESULTS:
Beta activity was significantly reduced on Christmas Eve in all patients (4.00-9.00 p.m. -12.30 ± 10.78%, P = 0.015). A sweet spot in the dorsolateral STN connected recording sites to motor, premotor, and supplementary motor cortices.CONCLUSIONS:
We demonstrate that festive events can reduce beta biomarker activity. We conclude that circadian and holiday-related changes should be considered when tailoring adaptive DBS algorithms to patient demands. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Núcleo Subtalâmico
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Estimulação Encefálica Profunda
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Córtex Motor
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article