Deciphering Adult Neural Stem Cells with Single-Cell Sequencing.
Stem Cells Dev
; 32(9-10): 213-224, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36721381
ABSTRACT
Adult neural stem cells (NSCs) are restricted to the two neurogenic regions of the mammalian brain, where they self-renew and generate progenies of multiple lineages, including neurons, astrocytes, and oligodendrocytes. Single-cell RNA sequencing technology, which reconstructs high-resolution transcriptional landscapes, provides valuable insights into cellular heterogeneity and developmental dynamics. In this review, we overviewed recent progress in the single-cell analyses of both conventional and unconventional NSCs. We discussed the heterogeneity among the stem cell pool and characterized the transcriptional alterations in aging and brain tumors. A comprehensive understanding of NSCs in physiological and pathological settings will provide insights for the rejuvenation of the aged brain and restoration of normal brain function in multiple neurological disorders.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Adultas
/
Células-Tronco Neurais
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article