8-Hydroxyquinoline derivatives suppress GLI1-mediated transcription through multiple mechanisms.

Wen, Jiachen; Charan Dash, Radha; Zaino, Angela M; Harrahill, Noah J; Calhoun, Jackson T; Dusek, Christopher O; Morel, Shana R; Russolillo, Matthew; Kyle Hadden, M

Wen, Jiachen; Charan Dash, Radha; Zaino, Angela M; Harrahill, Noah J; Calhoun, Jackson T; Dusek, Christopher O; Morel, Shana R; Russolillo, Matthew; Kyle Hadden, M.

Afiliação

Wen J; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06029-3092, United States.
Charan Dash R; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06029-3092, United States.
Zaino AM; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06029-3092, United States.
Harrahill NJ; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06029-3092, United States.
Calhoun JT; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06029-3092, United States.
Dusek CO; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06029-3092, United States.
Morel SR; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06029-3092, United States.
Russolillo M; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06029-3092, United States.
Kyle Hadden M; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06029-3092, United States. Electronic address: kyle.hadden@uconn.edu.

Bioorg Chem ; 132: 106387, 2023 03.

Article em En | MEDLINE | ID: mdl-36724660

Assuntos

Neoplasias; Fatores de Transcrição; Humanos; Fatores de Transcrição/metabolismo; Proteína GLI1 em Dedos de Zinco/metabolismo; Proteínas Hedgehog/metabolismo; Transdução de Sinais; Proliferação de Células; Linhagem Celular Tumoral

Palavras-chave

8-Hydroxyquinoline; GLI1 inhibitor; Hedgehog pathway; Src kinase; Structure-based drug design

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Neoplasias Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Neoplasias Idioma: En Ano de publicação: 2023 Tipo de documento: Article