Amentoflavone induces caspase-dependent/-independent apoptosis and dysregulates cyclin-dependent kinase-mediated cell cycle in colorectal cancer in vitro and in vivo.

Lin, Cheng-Hsun; Lin, Kuang-Hsuan; Ku, Hsiang-Ju; Lee, Kun-Ching; Lin, Song-Shei; Hsu, Fei-Ting

Lin, Cheng-Hsun; Lin, Kuang-Hsuan; Ku, Hsiang-Ju; Lee, Kun-Ching; Lin, Song-Shei; Hsu, Fei-Ting.

Afiliação

Lin CH; Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Lin KH; Department of Radiation Oncology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
Ku HJ; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Lee KC; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Lin SS; Department of Radiation Oncology, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan.
Hsu FT; Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan.

Environ Toxicol ; 38(5): 1078-1089, 2023 May.

Article em En | MEDLINE | ID: mdl-36727907

Assuntos

Neoplasias Colorretais; Quinases Ciclina-Dependentes; Animais; Quinases Ciclina-Dependentes/metabolismo; Quinases Ciclina-Dependentes/farmacologia; Proteína Supressora de Tumor p53/metabolismo; Linhagem Celular Tumoral; Ciclo Celular; Apoptose; Caspases/metabolismo; Neoplasias Colorretais/patologia; Inibidor de Quinase Dependente de Ciclina p21/metabolismo

Palavras-chave

G1 arrest; amentoflavone; caspase-dependent apoptosis; caspase-independent apoptosis; colorectal cancer; cyclin-dependent kinase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Quinases Ciclina-Dependentes Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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