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Dysosmaflavonoid A-F, new flavonols with potent DPPH radical scavenging activity from Dysosma versipellis.
Sun, Yan-Jun; Bai, Hong-Yun; Han, Rui-Jie; Zhao, Qi-Lu; Li, Meng; Chen, Hui; Si, Ying-Ying; Xue, Gui-Min; Zhao, Zhen-Zhu; Feng, Wei-Sheng.
Afiliação
  • Sun YJ; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
  • Bai HY; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
  • Han RJ; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
  • Zhao QL; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
  • Li M; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
  • Chen H; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
  • Si YY; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
  • Xue GM; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
  • Zhao ZZ; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
  • Feng WS; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 4500
Fitoterapia ; 166: 105440, 2023 Apr.
Article em En | MEDLINE | ID: mdl-36736596
Six new flavonols, including four glucosylated flavonols (dysosmaflavonoid A-D), one phenylpropanoid-substituted flavonol (dysosmaflavonoid E), and one phenyl-substituted flavonol (dysosmaflavonoid F), together with five known analogues, were isolated from the roots and rhizomes of Dysosma versipellis. Their structures were elucidated by comprehensive analysis of their NMR, IR, UV, HRESIMS, and HPLC data. The antioxidant activities of all isolated compounds were examined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Compounds 2, 3, 5-8, and 12 exhibited significant DPPH scavenging capacity with IC50 values of 33.95, 39.02, 31.17, 32.79, 31.85, 30.48, and 23.75 µM, respectively, in comparison with Trolox (IC50, 15.80 µM). Compound 12 displayed more potent DPPH radical scavenging activity than prenylated and (or) glucosided derivatives (2-4, or 10). The preliminary structure-activity relationship showed that the catechol structure in flavonol is essential for DPPH radical scavenging effect.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Berberidaceae / Flavonóis Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Berberidaceae / Flavonóis Idioma: En Ano de publicação: 2023 Tipo de documento: Article