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Development and validation of an analytical method for trace-level quantification of genotoxic nitrosamine impurities in losartan and hydrochlorothiazide fixed-dose combination tablets using ultra performance liquid chromatography triple quadrupole mass spectrometry.
Patel, Ravi; Purohit, Sanjay; Solanki, Ravisinh; Khunt, Dignesh; Patel, Chhaganbhai; Patel, Rucha; Parikh, Shalin.
Afiliação
  • Patel R; Department of Quality Assurance, Graduate School of Pharmacy, Gujarat Technological University, Gandhinagar, India.
  • Purohit S; Department of Quality Assurance, Graduate School of Pharmacy, Gujarat Technological University, Gandhinagar, India.
  • Solanki R; Department of Quality Assurance, Graduate School of Pharmacy, Gujarat Technological University, Gandhinagar, India.
  • Khunt D; Department of Pharmaceutics, Graduate School of Pharmacy, Gujarat Technological University, Gandhinagar, India.
  • Patel C; Department of Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Mehsana, India.
  • Patel R; Regulatory Affairs Division, JAMP INDIA Pharmaceutical Pvt. Ltd., Ahmedabad, India.
  • Parikh S; Analytical Development Division, Senores Pharmaceuticals, Ahmedabad, India.
Rapid Commun Mass Spectrom ; 37(8): e9488, 2023 Apr 30.
Article em En | MEDLINE | ID: mdl-36740827
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Losartan / Nitrosaminas Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Losartan / Nitrosaminas Idioma: En Ano de publicação: 2023 Tipo de documento: Article