Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging.
Org Biomol Chem
; 21(14): 2889-2893, 2023 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-36744956
ABSTRACT
The C4N4 fluorophore is an intense fluorescence emitter featuring a 2,5-diaminopyrimidine core comprising four carbon and four nitrogen atoms. A series of C4N4 derivatives was photochemically dimerized at the 5-amino group, furnishing overcrowded ortho-tetraaryl-substituted diaryl azo compounds with a characteristic skewed structure revealed by X-ray crystallography. The photoquenched azo-C4N4s are useful for fluorescently visualizing cells under hypoxic conditions.
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MEDLINE
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En
Ano de publicação:
2023
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Article