Gaucher disease protects against tuberculosis.

Fan, Jingwen; Hale, Victoria L; Lelieveld, Lindsey T; Whitworth, Laura J; Busch-Nentwich, Elisabeth M; Troll, Mark; Edelstein, Paul H; Cox, Timothy M; Roca, Francisco J; Aerts, Johannes M F G; Ramakrishnan, Lalita

Fan, Jingwen; Hale, Victoria L; Lelieveld, Lindsey T; Whitworth, Laura J; Busch-Nentwich, Elisabeth M; Troll, Mark; Edelstein, Paul H; Cox, Timothy M; Roca, Francisco J; Aerts, Johannes M F G; Ramakrishnan, Lalita.

Afiliação

Fan J; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, UK.
Hale VL; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Lelieveld LT; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Whitworth LJ; Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University 2333 CC, Leiden, The Netherlands.
Busch-Nentwich EM; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, UK.
Troll M; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Edelstein PH; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, UK.
Cox TM; School of Biological and Behavioral Sciences, Queen Mary University of London, London E1 4NS, UK.
Roca FJ; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, UK.
Aerts JMFG; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Ramakrishnan L; Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, UK.

Proc Natl Acad Sci U S A ; 120(7): e2217673120, 2023 02 14.

Article em En | MEDLINE | ID: mdl-36745788

Assuntos

Doença de Gaucher; Tuberculose; Animais; Doença de Gaucher/genética; Peixe-Zebra/genética; Glucosilceramidase/genética; Mutação; Tuberculose/genética; Tuberculose/prevenção & controle

Palavras-chave

Gaucher disease; lysosomal glucosylsphingosine; macrophages; tuberculosis resistance; zebrafish

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Doença de Gaucher Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Doença de Gaucher Idioma: En Ano de publicação: 2023 Tipo de documento: Article