L3MBTL3 is induced by HIF-1&#945; and fine tunes the HIF-1&#945; degradation under hypoxia in vitro.

L3MBTL3 is induced by HIF-1α and fine tunes the HIF-1α degradation under hypoxia in vitro.

Wang, Mengdong; Wang, Di; Lang, Yue; Shao, Anwen; Zhang, Rui; Tang, Jun; Lai, Dongming; Xiao, Chenglu.

Afiliação

Wang M; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Wang D; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Lang Y; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Shao A; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Zhang R; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Tang J; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Lai D; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, NO. 107, Yanjiangxi Road, Guangzhou, 510120, China.
Xiao C; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

Heliyon ; 9(2): e13222, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36747531

Palavras-chave

ARNT, aryl hydrocarbon receptor nuclear translocator; CHX, cycloheximide; FCS, phenylalanine-cysteine-serine nucleic acid−binding; HIF-1, hypoxia inducible factor 1; HIF-1α; HIF-1α degradation; HRE, hypoxia response element; Hypoxia; L3MBTL3; L3MBTL3, lethal (3) malignant brain tumor-like 3; MBT, malignant brain tumor; PHD, prolyl hydroxylase domain; SAM, sterile α motif; VHL, von Hippel-Lindau

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article