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Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson's disease.
Sastre, Danuta; Zafar, Faria; Torres, C Alejandra Morato; Piper, Desiree; Kirik, Deniz; Sanders, Laurie H; Qi, Stanley; Schüle, Birgitt.
Afiliação
  • Sastre D; Stanford University School of Medicine, Department of Pathology, Stanford, CA 94305, U.S.A.
  • Zafar F; Stanford University School of Medicine, Department of Pathology, Stanford, CA 94305, U.S.A.
  • Torres CAM; Stanford University School of Medicine, Department of Pathology, Stanford, CA 94305, U.S.A.
  • Piper D; San Jose State University, Department of Biological Sciences, San Jose, 95192 CA, U.S.A.
  • Kirik D; Department of Experimental Medical Science, Lund University, Lund, Sweden.
  • Sanders LH; Departments of Neurology and Pathology, Duke Center for Neurodegeneration and Neurotherapeutics, Duke University Medical Center, Durham, NC 27710, U.S.A.
  • Qi S; Stanford University, Department of Bioengineering, Stanford, CA 94305, U.S.A.
  • Schüle B; Stanford University School of Medicine, Department of Pathology, Stanford, CA 94305, U.S.A.
bioRxiv ; 2023 Jan 24.
Article em En | MEDLINE | ID: mdl-36747875
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article