Metal-Free Highly Regioselective 1,4-Sulfonyliodination of 1,3-Enynes.
J Org Chem
; 88(4): 2034-2045, 2023 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-36749192
ABSTRACT
Herein, a novel, practical, and green synthetic method using readily available 1,3-enynes with sulfonyl hydrazides and I2 through tert-butyl hydroperoxide (TBHP)-mediated 1,4-sulfonyliodination has been developed for synthesizing various tetrasubstituted allenyl iodides under metal-free conditions. Notably, the proposed method exhibits a broad substrate scope, operational simplicity, tolerance to air, high functional-group tolerance, satisfactory yields, and excellent regioselectivity as well as involves the use of cost-effective reagents such as green oxidants.
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MEDLINE
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En
Ano de publicação:
2023
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Article