Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient.

Gude, Fabian; Froese, Jurij; Manikowski, Dominique; Di Iorio, Daniele; Grad, Jean-Noël; Wegner, Seraphine; Hoffmann, Daniel; Kennedy, Melissa; Richter, Ralf P; Steffes, Georg; Grobe, Kay

Gude, Fabian; Froese, Jurij; Manikowski, Dominique; Di Iorio, Daniele; Grad, Jean-Noël; Wegner, Seraphine; Hoffmann, Daniel; Kennedy, Melissa; Richter, Ralf P; Steffes, Georg; Grobe, Kay.

Afiliação

Gude F; From the Institute for Physiological Chemistry and Pathobiochemistry, University of Münster, 48149, Münster, Germany.
Froese J; From the Institute for Physiological Chemistry and Pathobiochemistry, University of Münster, 48149, Münster, Germany.
Manikowski D; From the Institute for Physiological Chemistry and Pathobiochemistry, University of Münster, 48149, Münster, Germany.
Di Iorio D; From the Institute for Physiological Chemistry and Pathobiochemistry, University of Münster, 48149, Münster, Germany.
Grad JN; The Institute for Bioinformatics and Computational Biophysics, University of Duisburg-Essen, 45117, Essen, Germany.
Wegner S; Institute for Computational Physics, Universität Stuttgart, Allmandring 3, 70569, Stuttgart, Germany.
Hoffmann D; From the Institute for Physiological Chemistry and Pathobiochemistry, University of Münster, 48149, Münster, Germany.
Kennedy M; The Institute for Bioinformatics and Computational Biophysics, University of Duisburg-Essen, 45117, Essen, Germany.
Richter RP; The School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
Steffes G; The School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK.
Grobe K; The Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.

Nat Commun ; 14(1): 758, 2023 02 10.

Article em En | MEDLINE | ID: mdl-36765094

Assuntos

Proteínas de Drosophila; Animais; Proteínas de Drosophila/genética; Proteínas de Drosophila/metabolismo; Proteínas Hedgehog/genética; Proteínas Hedgehog/metabolismo; Heparitina Sulfato/metabolismo; Drosophila/metabolismo; Sítios de Ligação; Drosophila melanogaster/metabolismo; Asas de Animais

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Drosophila Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Drosophila Idioma: En Ano de publicação: 2023 Tipo de documento: Article