Myelin Basic Protein Fragmentation by Engineered Human Proteasomes with Different Catalytic Phenotypes Revealed Direct Peptide Ligands of MS-Associated and Protective HLA Class I Molecules.

Saratov, George A; Vladimirov, Vasiliy I; Novoselov, Alexey L; Ziganshin, Rustam H; Chen, Guo; Baymukhametov, Timur N; Konevega, Andrey L; Belogurov, Alexey A; Kudriaeva, Anna A

Saratov, George A; Vladimirov, Vasiliy I; Novoselov, Alexey L; Ziganshin, Rustam H; Chen, Guo; Baymukhametov, Timur N; Konevega, Andrey L; Belogurov, Alexey A; Kudriaeva, Anna A.

Afiliação

Saratov GA; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Vladimirov VI; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (National Research University), 141701 Dolgoprudny, Russia.
Novoselov AL; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Ziganshin RH; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Chen G; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Baymukhametov TN; School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China.
Konevega AL; National Research Center, "Kurchatov Institute", 123182 Moscow, Russia.
Belogurov AA; National Research Center, "Kurchatov Institute", 123182 Moscow, Russia.
Kudriaeva AA; Institute of Biomedical Systems and Biotechnologies, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.

Int J Mol Sci ; 24(3)2023 Jan 20.

Article em En | MEDLINE | ID: mdl-36768413

Assuntos

Esclerose Múltipla; Proteína Básica da Mielina; Animais; Humanos; Proteína Básica da Mielina/metabolismo; Complexo de Endopeptidases do Proteassoma; Ligantes; Fragmentos de Peptídeos; Peptídeos/química; Esclerose Múltipla/genética; Epitopos Imunodominantes; Antígenos HLA-A; Mamíferos/metabolismo

Palavras-chave

HLA class I; HTBH; IFNÎ³; biotin carboxyl carrier domain; immunoproteasome; multiple sclerosis; myelin basic protein; negative stain electron microscopy; proteasome; sodium dodecyl sulfate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Básica da Mielina / Esclerose Múltipla Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Básica da Mielina / Esclerose Múltipla Idioma: En Ano de publicação: 2023 Tipo de documento: Article