A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors.

Mahajan, Pankaj S; Smith, Steven J; Hughes, Stephen H; Zhao, Xuezhi; Burke, Terrence R

Mahajan, Pankaj S; Smith, Steven J; Hughes, Stephen H; Zhao, Xuezhi; Burke, Terrence R.

Afiliação

Mahajan PS; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Smith SJ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Hughes SH; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Zhao X; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Burke TR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

Molecules ; 28(3)2023 Feb 02.

Article em En | MEDLINE | ID: mdl-36771093

Assuntos

Infecções por HIV; Inibidores de Integrase de HIV; Integrase de HIV; Humanos; Piridonas/química; Raltegravir Potássico/farmacologia; Inibidores de Integrase de HIV/química; Farmacorresistência Viral; Integrase de HIV/química; Antivirais/farmacologia; Antivirais/uso terapêutico; Compostos Heterocíclicos com 3 Anéis/farmacologia; Infecções por HIV/tratamento farmacológico

Palavras-chave

HIV-1; bicyclic carbamoyl pyridones; catalytic hydrogenation; integrase strand transfer inhibitor (INSTI); metal chelation; one-pot synthesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Inibidores de Integrase de HIV / Integrase de HIV Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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