Investigating the chemical profile of Rheum lhasaense and its main ingredient of piceatannol-3'-O-ß-D-glucopyranoside on ameliorating cognitive impairment.

Wang, Yue; Liu, Qing; Lv, Qiuyue; Yang, Kailin; Wu, Xinyan; Zheng, Yaping; Xiao, Peigen; Jiang, Baoping; He, Chunnian

Wang, Yue; Liu, Qing; Lv, Qiuyue; Yang, Kailin; Wu, Xinyan; Zheng, Yaping; Xiao, Peigen; Jiang, Baoping; He, Chunnian.

Afiliação

Wang Y; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
Liu Q; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
Lv Q; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
Yang K; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
Wu X; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
Zheng Y; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
Xiao P; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
Jiang B; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China. Electronic address: baoping.jiang@163.com.
He C; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China. Electronic address: cnhe@implad.ac.cn.

Biomed Pharmacother ; 160: 114394, 2023 Apr.

Article em En | MEDLINE | ID: mdl-36774724

Assuntos

Doenças Neurodegenerativas; Rheum; Estilbenos; Camundongos; Animais; Rheum/química; Espectrometria de Massas em Tandem; Secretases da Proteína Precursora do Amiloide; Metaloproteinase 3 da Matriz; Simulação de Acoplamento Molecular; Ácido Aspártico Endopeptidases; Estilbenos/farmacologia; Estilbenos/uso terapêutico; Estilbenos/química; Derivados da Escopolamina

Palavras-chave

Chemical profile; Cognitive impairment; Mechanism; Piceatannol-3'-O-ß-D-glucopyranoside; Rheum lhasaense; UPLC-Q-TOF-MS/MS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rheum / Estilbenos / Doenças Neurodegenerativas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rheum / Estilbenos / Doenças Neurodegenerativas Idioma: En Ano de publicação: 2023 Tipo de documento: Article