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Regio- and chemoselective hydroamination of unactivated alkenes with anthranils via NiH-catalysis.
Zheng, Yan-Long; Liang, Di-Yu; Ma, Hong-Bin; Meng, Fan-Cheng; Wang, Tie.
Afiliação
  • Zheng YL; Tianjin Key Laboratory of Drug Targeting and Bioimaging, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin, 300384, P. R. China. ylzheng@email.tjut.edu.cn.
  • Liang DY; Tianjin Key Laboratory of Drug Targeting and Bioimaging, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin, 300384, P. R. China. ylzheng@email.tjut.edu.cn.
  • Ma HB; Tianjin Key Laboratory of Drug Targeting and Bioimaging, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin, 300384, P. R. China. ylzheng@email.tjut.edu.cn.
  • Meng FC; Tianjin Key Laboratory of Drug Targeting and Bioimaging, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin, 300384, P. R. China. ylzheng@email.tjut.edu.cn.
  • Wang T; Tianjin Key Laboratory of Drug Targeting and Bioimaging, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin, 300384, P. R. China. ylzheng@email.tjut.edu.cn.
Chem Commun (Camb) ; 59(19): 2751-2754, 2023 Mar 02.
Article em En | MEDLINE | ID: mdl-36779354
ABSTRACT
A NiH-catalyzed polarity-reversed hydroamination of ß,γ-, γ,δ- and δ,ε-unsaturated alkenes with electrophilic anthranils was developed. This reaction proceeds in a highly regio- and chemoselective manner to afford γ, δ and ε-arylamines bearing a carbonyl or alcohol functionality with 100% atom efficiency. Preliminary mechanistic studies indicate that the chemoselectivity is controlled by the base and the alcohol product is derived from the base-catalyzed hydrosilylation of the CO bond.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article