Regio- and chemoselective hydroamination of unactivated alkenes with anthranils via NiH-catalysis.
Chem Commun (Camb)
; 59(19): 2751-2754, 2023 Mar 02.
Article
em En
| MEDLINE
| ID: mdl-36779354
ABSTRACT
A NiH-catalyzed polarity-reversed hydroamination of ß,γ-, γ,δ- and δ,ε-unsaturated alkenes with electrophilic anthranils was developed. This reaction proceeds in a highly regio- and chemoselective manner to afford γ, δ and ε-arylamines bearing a carbonyl or alcohol functionality with 100% atom efficiency. Preliminary mechanistic studies indicate that the chemoselectivity is controlled by the base and the alcohol product is derived from the base-catalyzed hydrosilylation of the CîO bond.
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MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article