Prognostic impact of CD4+ and CD8+ tumor-infiltrating lymphocytes in patients with colorectal cancer.
Acta Chir Belg
; 124(1): 35-40, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-36780176
ABSTRACT
OBJECTIVE:
Tumor immune response has been suggested as an important indicator of cancer prognosis. This study was initiated to investigate the association between T lymphocytes and the prognosis of patients with colorectal cancer (CRC).METHODS:
Included in this study were 129 CRC patients who received surgical treatment in Henan Provincial People's Hospital from January 2003 to January 2014. The level of CD4+ and CD8+ T lymphocytes in tissues was detected by immunohistochemistry (IHC). Survival analysis was conducted by the Kaplan-Meier method and Cox proportional hazards model.RESULTS:
IHC staining showed that CD8+ T lymphocyte infiltration was high in 88 cases and low in 41 cases, while CD4+ T lymphocyte infiltration was high in 66 cases and low in 63 cases. The level of CD4+ and CD8+ T lymphocytes in CRC tissue was closely related to TNM stage and tumor invasion (p < 0.05). Follow-up analysis showed that both disease-free survival (DFS) and overall survival (OS) were better in patients with a high level of CD8+ and CD4 + CD8+ than those in patients with a low level (p < 0.05). Multivariate analysis showed that TNM stage, lymph node, CD8+ and CD4+ CD8+ were independent risk factors for DFS and OS (p < 0.05).CONCLUSION:
High level of CD8+ and CD4+ CD8+ may prove to be a potential predictor of better prognosis of CRC patients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Linfócitos do Interstício Tumoral
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article