Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition.

Pitcairn, Caleb; Murata, Naomi; Zalon, Annie J; Stojkovska, Iva; Mazzulli, Joseph R

Pitcairn, Caleb; Murata, Naomi; Zalon, Annie J; Stojkovska, Iva; Mazzulli, Joseph R.

Afiliação

Pitcairn C; The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Murata N; The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Zalon AJ; The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Stojkovska I; The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Mazzulli JR; The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 jmazzulli@northwestern.edu.

J Neurosci ; 43(14): 2615-2629, 2023 04 05.

Article em En | MEDLINE | ID: mdl-36788031

Assuntos

Doença de Parkinson; Humanos; Masculino; Camundongos; Animais; Feminino; Doença de Parkinson/metabolismo; Farnesiltranstransferase/metabolismo; alfa-Sinucleína/metabolismo; Autofagia/fisiologia; Mesencéfalo/metabolismo; Neurônios/metabolismo; Lisossomos/metabolismo; Proteínas SNARE/metabolismo; Hidrolases/metabolismo; Proteínas R-SNARE/metabolismo

Palavras-chave

farnesyltransferase; iPSC; macroautophagy; midbrain neurons; protein aggregation; α-synuclein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson Idioma: En Ano de publicação: 2023 Tipo de documento: Article