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Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease.
Xu, Junhua; Cai, Hongwei; Wu, Zhuhao; Li, Xiang; Tian, Chunhui; Ao, Zheng; Niu, Vivian C; Xiao, Xiao; Jiang, Lei; Khodoun, Marat; Rothenberg, Marc; Mackie, Ken; Chen, Jun; Lee, Luke P; Guo, Feng.
Afiliação
  • Xu J; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.
  • Cai H; Biopharmaceutical Research Institute, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
  • Wu Z; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.
  • Li X; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.
  • Tian C; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.
  • Ao Z; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.
  • Niu VC; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.
  • Xiao X; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.
  • Jiang L; Bloomington High School South, Bloomington, IN, 47401, USA.
  • Khodoun M; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Rothenberg M; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.
  • Mackie K; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, 45229, USA.
  • Chen J; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, 45229, USA.
  • Lee LP; Gill Center for Biomolecular Science, and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA.
  • Guo F; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. jun.chen@ucla.edu.
Nat Commun ; 14(1): 869, 2023 02 16.
Article em En | MEDLINE | ID: mdl-36797284
ABSTRACT
Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability to timely administrate therapeutics and precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand acute disease management. Through the integration of active acoustic metamaterials, a compact therapeutic patch is integrated for penetration of skin stratum corneum and active percutaneous transport of therapeutics with precise control of dose and rate over time. Moreover, the patch device quantitatively regulates the dosage and release kinetics of therapeutics and achieves better delivery performance in vivo than through subcutaneous injection. As a proof-of-concept application, we show our method can reverse life-threatening acute allergic reactions in a female mouse model of anaphylaxis via a multi-burst delivery of epinephrine, showing better efficacy than a fixed dosage injection of epinephrine, which is the current gold standard 'self-injectable epinephrine' strategy. This innovative method may provide a promising means to manage acute disease for personalized medicine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Sistemas de Liberação de Medicamentos Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Sistemas de Liberação de Medicamentos Idioma: En Ano de publicação: 2023 Tipo de documento: Article