Discovery of microglia gonadotropinreleasing hormone receptor and its potential role in polycystic ovarian syndrome.
Mol Med Rep
; 27(4)2023 04.
Article
em En
| MEDLINE
| ID: mdl-36799164
ABSTRACT
Hypothalamic inflammation is a pathophysiological basis of polycystic ovarian syndrome (PCOS), while overactivated and/or excess M1 polarized microglia are considered to be the main reason for the occurrence of hypothalamic inflammation. Therefore, in vitro and in vivo experiments were performed to assess the relationships between microgliamediated inflammatory reactions and endocrine functions in the PCOS hypothalamus. The expression of gonadotropinreleasing hormone (GnRH) receptor (GnRHR) was demonstrated in hypothalamic microglia, and it was found that low concentration, GnRH agonist, leuprolide acetate accelerated the expression of M2 polarization marker CD206, while high concentration leuprolide acetate increased the expression of M1 polarization marker CD86 in vitro. Furthermore, aerobic exercise not only reduced the levels of serum testosterone, luteinizing hormone and GnRH and the amount of overactivated microglia, but also increased the number of M2 microglia in the hypothalamus of letrozoleinduced PCOS rats. In combination, these results not only demonstrated the expression of GnRHR in hypothalamic microglia, but also demonstrated that GnRH can induce microglial polarization, while aerobic exercise may improve the microgliamediated inflammatory reaction by reducing the expression of GnRHR in the hypothalamic microglia of PCOS rats.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article