Synthetic benzofuran-linked chalcones with dual actions: a potential therapeutic approach to manage diabetes mellitus.
Future Med Chem
; 15(2): 167-187, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36799245
ABSTRACT
Background:
Identification of molecules having dual capabilities to reduce postprandial hyperglycemia and oxidative stress is one of the therapeutic approaches to treat diabetes mellitus. In this connection, a library of benzofuran-linked chalcone derivatives were evaluated for their dual action.Methods:
A series of substituted benzofuran-linked chalcones (2-33) were synthesized and tested for α-amylase inhibitory as well as 2,2-diphenylpicrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activities.Results:
All compounds showed α-amylase inhibitory activity ranging from IC50 = 12.81 ± 0.03 to 87.17 ± 0.15 µM, compared with the standard acarbose (IC50 = 13.98 ± 0.03 µM). Compounds also demonstrated radical scavenging potential against DPPH and ABTS radicals.Conclusion:
The identified compounds may serve as potential leads for further advanced research.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzofuranos
/
Chalconas
/
Diabetes Mellitus
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article