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Making bubbles: Targeting VPS41 induces vacuolization and methuosis.
Dekker, Nienke Julia; Laraia, Luca.
Afiliação
  • Dekker NJ; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark.
  • Laraia L; Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kongens Lyngby, Denmark. Electronic address: luclar@kemi.dtu.dk.
Cell Chem Biol ; 30(2): 127-129, 2023 02 16.
Article em En | MEDLINE | ID: mdl-36800990
In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer cell lines, validating VPS41 as a potential therapeutic target.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Vacúolos Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Vacúolos Idioma: En Ano de publicação: 2023 Tipo de documento: Article