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Glyphosate exposure and preterm birth: A nested case-control pilot study.
Varde, Meghana; Gerona, Roy R; Newman, Roger B; Reckers, Andrew; Braak, David C; Vena, John E; Bloom, Michael S.
Afiliação
  • Varde M; Department of Global and Community Health, George Mason University, 4400 University Dr., MS 5B7, Fairfax, VA, 22030, USA.
  • Gerona RR; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, 2340 Sutter St, S-232, San Francisco, CA, 94115, USA.
  • Newman RB; Department of Obstetrics and Gynecology, Medical University of South Carolina, Rm 634, Clinical Science Bldg., 96 Jonathan Lucas St., Charleston, SC 29425, USA.
  • Reckers A; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, 2340 Sutter St, S-232, San Francisco, CA, 94115, USA.
  • Braak DC; Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon St.; MSC 835, Charleston, SC, 29455, USA; Intermountain Healthcare, Utah Valley Hospital, 1034 N 500 W., Provo, UT 84604, USA.
  • Vena JE; Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon St.; MSC 835, Charleston, SC, 29455, USA. Electronic address: vena@musc.edu.
  • Bloom MS; Department of Global and Community Health, George Mason University, 4400 University Dr., MS 5B7, Fairfax, VA, 22030, USA. Electronic address: mbloom22@gmu.edu.
Reprod Toxicol ; 117: 108350, 2023 04.
Article em En | MEDLINE | ID: mdl-36803739
Preterm birth (PTB) is associated with a high risk of infant mortality and long-term adverse health effects. Glyphosate is a broad-spectrum herbicide applied in agricultural and non-agricultural settings. Studies suggested an association between maternal exposure to glyphosate and PTB among mostly racially homogenous populations, though results were inconsistent. The objective of this pilot study was to inform the design of a larger and more definitive study of glyphosate exposure and adverse birth outcomes in a racially-diverse population. Urine was obtained from 26 women with a PTB as cases and 26 women with a term birth as controls, from participants enrolled in a birth cohort in Charleston, South Carolina. We used binomial logistic regression to estimate associations between urinary glyphosate and the odds of PTB, and multinomial regression to estimate associations between maternal racial identity and urinary glyphosate among controls. Glyphosate was unrelated to PTB (odds ratio (OR) = 1.06, 95% CI: 0.61, 1.86). Women who identified as Black had greater odds (OR = 3.83, 95% CI: 0.13, 111.33) of having categorical "high" glyphosate (> 0.28 ng/mL) and lesser odds (OR = 0.79, 95% CI: 0.05, 12.21) of "low" glyphosate (< 0.03 ng/mL) relative to women who identified as white, suggesting a potential racial disparity, although the effect estimates were imprecise and included the null. Given concerns of potential reproductive toxicity of glyphosate, the results merit confirmation in a larger investigation to determine specific sources of glyphosate exposure, incorporating longitudinal urinary glyphosate measures during pregnancy and a comprehensive measure of diet.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nascimento Prematuro Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nascimento Prematuro Idioma: En Ano de publicação: 2023 Tipo de documento: Article