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Protection against severe COVID-19 after second booster dose of adapted bivalent (original/Omicron BA.4-5) mRNA vaccine in persons ≥ 60 years, by time since infection, Italy, 12 September to 11 December 2022.
Fabiani, Massimo; Mateo-Urdiales, Alberto; Sacco, Chiara; Fotakis, Emmanouil Alexandros; Rota, Maria Cristina; Petrone, Daniele; Bressi, Marco; Del Manso, Martina; Siddu, Andrea; Fedele, Giorgio; Stefanelli, Paola; Bella, Antonino; Riccardo, Flavia; Palamara, Anna Teresa; Rezza, Giovanni; Brusaferro, Silvio; Pezzotti, Patrizio.
Afiliação
  • Fabiani M; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Mateo-Urdiales A; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Sacco C; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Fotakis EA; European Programme on Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden.
  • Rota MC; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Petrone D; European Programme on Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden.
  • Bressi M; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Del Manso M; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Siddu A; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Fedele G; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Stefanelli P; General Directorate of Prevention, Italian Ministry of Health, Rome, Italy.
  • Bella A; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Riccardo F; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Palamara AT; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Rezza G; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Brusaferro S; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
  • Pezzotti P; General Directorate of Prevention, Italian Ministry of Health, Rome, Italy.
Euro Surveill ; 28(8)2023 02.
Article em En | MEDLINE | ID: mdl-36820640
ABSTRACT
Effectiveness against severe COVID-19 of a second booster dose of the bivalent (original/BA.4-5) mRNA vaccine 7-90 days post-administration, relative to a first booster dose of an mRNA vaccine received ≥ 120 days earlier, was ca 60% both in persons ≥ 60 years never infected and in those infected > 6 months before. Relative effectiveness in those infected 4-6 months earlier indicated no significant additional protection (10%; 95% CI -44 to 44). A second booster vaccination 6 months after the latest infection may be warranted.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article