The aberrant epigenome of <i>DNMT3B</i>-mutated ICF1 patient iPSCs is amenable to correction, with the exception of a subset of regions with H3K4me3- and/or CTCF-based epigenetic memory.

Poondi Krishnan, Varsha; Morone, Barbara; Toubiana, Shir; Krzak, Monika; Fioriniello, Salvatore; Della Ragione, Floriana; Strazzullo, Maria; Angelini, Claudia; Selig, Sara; Matarazzo, Maria R

The aberrant epigenome of DNMT3B-mutated ICF1 patient iPSCs is amenable to correction, with the exception of a subset of regions with H3K4me3- and/or CTCF-based epigenetic memory.

Poondi Krishnan, Varsha; Morone, Barbara; Toubiana, Shir; Krzak, Monika; Fioriniello, Salvatore; Della Ragione, Floriana; Strazzullo, Maria; Angelini, Claudia; Selig, Sara; Matarazzo, Maria R.

Afiliação

Poondi Krishnan V; Institute of Genetics and Biophysics Adriano Buzzati Traverso, (IGB-ABT) CNR, Naples 80131, Italy.
Morone B; Institute of Genetics and Biophysics Adriano Buzzati Traverso, (IGB-ABT) CNR, Naples 80131, Italy.
Toubiana S; Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine and Research Institute, Technion, Haifa 31096, Israel.
Krzak M; Institute for Applied Computing (IAC) "Mauro Picone", CNR, Naples 80131 Italy.
Fioriniello S; Institute of Genetics and Biophysics Adriano Buzzati Traverso, (IGB-ABT) CNR, Naples 80131, Italy.
Della Ragione F; Institute of Genetics and Biophysics Adriano Buzzati Traverso, (IGB-ABT) CNR, Naples 80131, Italy.
Strazzullo M; IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Isernia 86077, Italy.
Angelini C; Institute of Genetics and Biophysics Adriano Buzzati Traverso, (IGB-ABT) CNR, Naples 80131, Italy; maria.matarazzo@igb.cnr.it claudia.angelini@cnr.it seligs@technion.ac.il.
Selig S; Institute for Applied Computing (IAC) "Mauro Picone", CNR, Naples 80131 Italy; maria.matarazzo@igb.cnr.it claudia.angelini@cnr.it seligs@technion.ac.il.
Matarazzo MR; Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine and Research Institute, Technion, Haifa 31096, Israel; maria.matarazzo@igb.cnr.it claudia.angelini@cnr.it seligs@technion.ac.il.

Genome Res ; 33(2): 169-183, 2023 02.

Article em En | MEDLINE | ID: mdl-36828588

Assuntos

Células-Tronco Pluripotentes Induzidas; Células-Tronco Pluripotentes Induzidas/metabolismo; Epigenoma; Memória Epigenética; Histonas/metabolismo; Metilação de DNA; DNA (Citosina-5-)-Metiltransferases/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas Idioma: En Ano de publicação: 2023 Tipo de documento: Article